Neurobiology of Disease IgG-Assisted Age-Dependent Clearance of Alzheimer’s Amyloid Peptide by the Blood–Brain Barrier Neonatal Fc Receptor

Rashid Deane,1* Abhay Sagare,1* Katie Hamm,1 Margaret Parisi,1 Barbra LaRue,1 Huang Guo,1 Zhenhua Wu,1 David M. Holtzman,2 and Berislav V. Zlokovic1 1Frank P. Smith Laboratories for Neuroscience and Neurosurgical Research, Department of Neurosurgery and Division of Neurovascular Biology, Arthur Kornberg Medical Research Building, University of Rochester Medical Center, Rochester, New York 14642, and 2Departments of Neurology, and Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110